Drug Information

Drug General Information
Drug ID
D02HSB
Former ID
DCL000502
Drug Name
Cabazitaxel
Synonyms
Jevtana; Taxoid XRP6258; Jevtana (TN)
Drug Type
Small molecular drug
Indication Breast cancer; Prostate cancer [ICD9: 174, 175, 185; ICD10:C50, C61] Approved [531351], [541879]
Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [531351], [541879]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C45H57NO14
InChI
InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
InChIKey
BMQGVNUXMIRLCK-OAGWZNDDSA-N
CAS Number
CAS 890654-44-1
PubChem Compound ID
9854073
PubChem Substance ID
14816121, 16397389, 24148765, 45276379, 74383470, 99443289, 103771484, 124490495, 126731257, 131408692, 135263012, 135611139, 142086497, 152159611, 160967906, 162202442, 162224746, 163620896, 163686217, 164834203, 174007406, 175267969, 176484653, 178103404, 184812013, 189628693, 198992513, 210024082, 221678515, 223662379, 224518787, 226540589, 243273959, 249582877, 251916124, 251917472, 251971415, 252110248, 252215082
SuperDrug ATC ID
L01CD04
Target and Pathway
Target(s) Tubulin Target Info Inhibitor [531351]
References
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 541879(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6798).
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.

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