Drug Information

Drug General Information
Drug ID
D02HUB
Former ID
DIB011230
Drug Name
Nestorone transdermal spray
Synonyms
Nestorone; Nestorone MDTS; Nestorone metered dose transdermal system; Nestorone transdermal spray, Acrux; ST-1435; Nestorone transdermal spray, Population Council/Acrux
Indication Endometriosis [ICD9: 617; ICD10:N80] Phase 3 [522001]
Company
Population Council; Population Council Center for Biomedical Research
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@]12([C@@](C(=C)C[C@H]1[C@H]1[C@@H]([C@@H]3C(=CC(=O)C<br />C3)CC1)CC2)(OC(=O)C)C(=O)C)C
CAS Number
CAS 7759-35-5
Target and Pathway
Target(s) Progesterone receptor Target Info Agonist [532946]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 522001ClinicalTrials.gov (NCT00455156) Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring. U.S. National Institutes of Health.
Ref 532946Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Nov 15;276(1-2):89-97.

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