Drug Information

Drug General Information
Drug ID
D02HVW
Former ID
DCL000665
Drug Name
Zibotentan
Synonyms
ZD4054; ZD-4054; ZD4054, Zibotentan; Zibotentan (JAN/INN); Trans,trans-2(4-methoxyphenyl)-4-(1-3-benzodiazol-5-yl)-1-(dibutylaminocarbonylmethyl)pyrrolidine-3-carboxylic acid; N-(3-methoxy-5-methyl-pyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3-sulfonamide
Drug Type
Small molecular drug
Indication Hormone resistant prostate cancer [ICD9: 185; ICD10:C61] Discontinued in Phase 3 [540471], [546670]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C19H16N6O4S
InChI
InChI=1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChIKey
FJHHZXWJVIEFGJ-UHFFFAOYSA-N
CAS Number
CAS 23713-49-7
PubChem Compound ID
9910224
PubChem Substance ID
14880486, 24190808, 45981884, 50077277, 68529939, 74721089, 85210245, 87550958, 93310545, 96024464, 99437161, 112379018, 124757263, 124950684, 124966603, 125164067, 125719303, 126651455, 126671547, 127855448, 131480882, 134339186, 135260946, 135368547, 136367429, 136920383, 137025840, 137275851, 141774639, 152048791, 152258082, 152344311, 160646921, 162011975, 162037610, 162202699, 162807569, 177748946, 178100518, 185998560, 196408601, 198974084, 223383997, 223662579, 223705164, 227118911, 242555952, 249582457, 249814523, 252216640
ChEBI ID
ChEBI:29105
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [550288]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540471(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3539).
Ref 546670Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009560)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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