Drug General Information
Drug ID
D02IJA
Former ID
DIB009986
Drug Name
Tau-binding PET tracer
Synonyms
T-777; T-807; T-808; Tau-binding PET tracer (Alzheimer disease); Tau-binding PET tracer (Alzheimer disease), Siemens
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [525148]
Company
Siemens Medical Solutions Molecular Imaging
Structure
Download
2D MOL

3D MOL

Formula
C16H10FN3
Canonical SMILES
C1=CC2=C(C=C1C3=CN=C(C=C3)F)NC4=C2C=NC=C4
InChI
1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H
InChIKey
GETAAWDSFUCLBS-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Microtubule-associated protein tau Target Info Modulator [531616]
KEGG Pathway MAPK signaling pathway
Alzheimer's disease
NetPath Pathway IL2 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database LPA receptor mediated events
Reelin signaling pathway
Reactome Caspase-mediated cleavage of cytoskeletal proteins
WikiPathways Notch Signaling Pathway
IL-2 Signaling Pathway
MAPK Signaling Pathway
Copper homeostasis
Kit receptor signaling pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Alzheimers Disease
Regulation of Microtubule Cytoskeleton
Apoptotic execution phase
IL-5 Signaling Pathway
References
Ref 525148ClinicalTrials.gov (NCT02414347) F 18 T807 Tau PET Imaging of Alzheimer's Disease. U.S. National Institutes of Health.
Ref 531616Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.