Drug Information

Drug General Information
Drug ID
D02IOC
Former ID
DNC000471
Drug Name
CP154,526
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Investigative [540433]
Structure
Download
2D MOL

3D MOL
Formula
C23H32N4
InChI
InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
InChIKey
FHQYJZCJRZHINA-UHFFFAOYSA-N
CAS Number
CAS 157286-86-7
PubChem Compound ID
5311055
PubChem Substance ID
7978994, 11056239, 12014900, 14901603, 39340784, 47434882, 47434883, 50040461, 57359338, 79925469, 103169859, 103954140, 112379028, 114155160, 127848689, 134339888, 135263133, 137007968, 160848904, 170507598, 178100483, 225118544, 231504719, 251963038
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [536307]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 540433(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3495).
Ref 536307A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68.

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