Drug Information

Drug General Information
Drug ID
D02IUX
Former ID
DIB020304
Drug Name
MA-2029
Synonyms
MA2029
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529236]
Structure
Download
2D MOL
Formula
C31H46ClFN4O4
InChI
InChI=1S/C31H45FN4O4.ClH/c1-9-34-28(38)24(18-21-12-15-26(37)23(16-21)31(4,5)6)35-29(39)27(19(2)3)36(8)30(40)25(33-7)17-20-10-13-22(32)14-11-20;/h10-16,19,24-25,27,33,37H,9,17-18H2,1-8H3,(H,34,38)(H,35,39);1H/t24-,25-,27-;/m0./s1
InChIKey
AMSDRHOIAWZBTJ-PBQYMGKRSA-N
PubChem Compound ID
73755070
PubChem Substance ID
178100861
Target and Pathway
Target(s) Motilin receptor Target Info Antagonist [529236]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529236Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur J Pharmacol. 2008 Mar10;581(3):296-305.
Ref 529236Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur J Pharmacol. 2008 Mar10;581(3):296-305.

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