Drug Information

Drug General Information
Drug ID
D02JXG
Former ID
DCL000975
Drug Name
SB-265610
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [531406]
Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [536223]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C14H9BrN6O
Canonical SMILES
C1=CC=C(C(=C1)NC(=O)NC2=CC=C(C3=NNN=C23)C#N)Br
InChI
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
InChIKey
SEDUMQWZEOMXSO-UHFFFAOYSA-N
CAS Number
CAS 211096-49-0
PubChem Compound ID
9841667
PubChem Substance ID
14803251, 44939744, 49684220, 57373509, 75246794, 103214422, 103998762, 124950693, 134339366, 134339409, 135698689, 135878311, 163124252, 163642037, 174007249, 188919974, 198956636, 204360500, 227736362, 241376092, 251963238, 252156739, 252160252
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [536223]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 531406SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.

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