Drug General Information
Drug ID	D02LSO
Former ID	DIB015549
Drug Name	P2Y1 antagonists
Synonyms	P2Y1 antagonists (thrombosis); P2Y1 antagonists (thrombosis), GlaxoSmithKline
Indication	Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Investigative	[529752]
Company	GlaxoSmithKline plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1ccc(cc1)N[C@H]1[C@@H]([C@H](N(c2c1cccc2)C(=O)Nc1cc(cc<br />(c1)Cl)Cl)CC)C
Target and Pathway
Target(s)	P2Y purinoceptor 1	Target Info	Antagonist	[543769]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	G alpha (q) signalling events
	P2Y receptors
	ADP signalling through P2Y purinoceptor 1
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529752	Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6222-6.
Ref 543769	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 323).

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