Drug Information
Drug General Information | |||||
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Drug ID |
D02LXI
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Former ID |
DIB020135
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Drug Name |
Ki16425
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539925] | ||
Structure |
Download2D MOL |
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Formula |
C24H25ClN2O5S
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InChI |
InChI=1S/C24H25ClN2O5S/c1-14-4-9-19(20(25)12-14)16(3)31-24(30)26-22-15(2)27-32-23(22)18-7-5-17(6-8-18)13-33-11-10-21(28)29/h4-9,12,16H,10-11,13H2,1-3H3,(H,26,30)(H,28,29)
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InChIKey |
NAKZZTXWHXCEPO-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Lysophosphatidic acid receptor Edg-2 | Target Info | Antagonist | [531748] | |
G protein coupled receptor 87 | Target Info | Antagonist | [529073] | ||
LPA2 receptor | Target Info | Antagonist | [526829] | ||
Lysophosphatidate-3 receptor | Target Info | Antagonist | [526829] | ||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
Pathway Interaction Database | LPA receptor mediated eventslysophospholipid_pathway:LPA receptor mediated events | ||||
References | |||||
Ref 526829 | Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol. 2003 Oct;64(4):994-1005. | ||||
Ref 529073 | The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. Epub 2007 Sep 24. | ||||
Ref 531748 | Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis. Int J Oncol. 2012 Apr;40(4):1133-41. |
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