Drug Information

Drug General Information
Drug ID
D02NCO
Former ID
DNC004859
Drug Name
T-98475
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538695]
Structure
Download
2D MOL

3D MOL
Formula
C37H37F2N3O4S
InChI
InChI=1S/C37H37F2N3O4S/c1-22(2)35(44)40-26-16-14-25(15-17-26)34-28(19-41(5)18-24-10-7-6-8-11-24)32-33(43)29(37(45)46-23(3)4)21-42(36(32)47-34)20-27-30(38)12-9-13-31(27)39/h6-17,21-23H,18-20H2,1-5H3,(H,40,44)
InChIKey
RANJJVIMTOIWIN-UHFFFAOYSA-N
PubChem Compound ID
9874838
PubChem Substance ID
45621815, 50112895, 56240336, 75529741, 85224672, 85789101, 103265018, 103961925, 104004218, 129101478, 134342064, 135651225, 135697667, 162023522, 163122169, 204359632, 233111552, 241375978, 249617594, 252089597, 252156580, 252160012, 252165017
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Inhibitor [529431]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538695(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1184).
Ref 529431J Med Chem. 2008 Jun 26;51(12):3331-48.Non-peptide gonadotropin-releasing hormone receptor antagonists.

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