Drug Information

Drug General Information
Drug ID
D02NNT
Former ID
DIB019310
Drug Name
compound 1d
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531435]
Structure
Download
2D MOL
Formula
C17H15F2N7
InChI
InChI=1S/C17H15F2N7/c1-9-5-15(26-25-9)23-17-13(19)6-11(7-20)16(24-17)22-10(2)14-4-3-12(18)8-21-14/h3-6,8,10H,1-2H3,(H3,22,23,24,25,26)/t10-/m0/s1
InChIKey
HIHOEGPXVVKJPP-JTQLQIEISA-N
PubChem Compound ID
53232451
PubChem Substance ID
124341313, 131272679, 131346662, 180420949, 239809889, 244871390, 249565803
Target and Pathway
Target(s) muscle, skeletal, receptor tyrosine kinase Target Info Inhibitor [531435]
Tyrosine-protein kinase JAK2 Target Info Inhibitor [531435]
FGF-3 receptor Target Info Inhibitor [531435]
Trk receptor Target Info Inhibitor [531435]
Tyrosine-protein kinase JAK3 Target Info Inhibitor [531435]
Proto-oncogene tyrosine-protein kinase receptor ret Target Info Inhibitor [531435]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Cholinergic synapse
Prolactin signaling pathway
Adipocytokine signaling pathway
Leishmaniasis
Toxoplasmosis
Tuberculosis
Measles
Influenza A
Herpes simplex infectionhsa04010:MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Endocytosis
Regulation of actin cytoskeleton
Pathways in cancer
MicroRNAs in cancer
Bladder cancer
Central carbon metabolism in cancerhsa04062:Chemokine signaling pathway
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Primary immunodeficiencyhsa04144:Endocytosis
Thyroid cancer
Central carbon metabolism in cancer
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
PI3 kinase pathway
CCKR signaling map STP00021:FGF signaling pathwayP00036:Interleukin signaling pathway
Pathway Interaction Database Endothelins
ErbB4 signaling events
GMCSF-mediated signaling events
IL4-mediated signaling events
IL27-mediated signaling events
Signaling events mediated by PTP1B
IL12-mediated signaling events
S1P3 pathway
SHP2 signaling
CXCR4-mediated signaling events
IL5-mediated signaling events
IFN-gamma pathway
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
IL6-mediated signaling events
PDGFR-beta signaling pathway
IL23-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Notch-mediated HES/HEY networkil4_2pathway:IL4-mediated signaling events
CD40/CD40L signaling
Signaling events mediated by TCPTP
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5ret_pathway:Signaling events regulated by Ret tyrosine kinase
Posttranslational regulation of adherens junction stability and dissassembly
Reactome Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
GPVI-mediated activation cascade
Prolactin receptor signaling
RMTs methylate histone arginines
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet productionR-HSA-2033514:FGFR3 mutant receptor activationR-HSA-170984:ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-114604:GPVI-mediated activation cascade
Interleukin-7 signaling
Interleukin-2 signaling
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Type II interferon signaling (IFNG)
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Mesodermal Commitment Pathway
Interleukin-2 signaling
Signaling by SCF-KIT
Prolactin receptor signaling
Growth hormone receptor signaling
JAK/STAT
BDNF signaling pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TSLP Signaling Pathway
IL17 signaling pathway
Leptin signaling pathway
TSH signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Interferon gamma signaling
Factors involved in megakaryocyte development and platelet production
IL-5 Signaling PathwayWP51:Regulation of Actin Cytoskeleton
Endochondral Ossification
Bladder Cancer
Neural Crest Differentiation
Signaling by FGFRWP382:MAPK Signaling Pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membraneWP49:IL-2 Signaling Pathway
Interleukin-7 signaling
IL-9 Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signalingWP706:SIDS Susceptibility Pathways
Dopaminergic Neurogenesis
References
Ref 531435In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61.
Ref 531435In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61.

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