Drug Information

Drug General Information
Drug ID
D02REJ
Former ID
DIB011251
Drug Name
JNJ-17216498
Synonyms
Histamine H3 antagonist (oral, narcolepsy) J&J
Indication Narcolepsy [ICD9: 347; ICD10:G47.4] Phase 2 [521955]
Company
Johnson & Johnson
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [527237]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 521955ClinicalTrials.gov (NCT00424931) A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsy. U.S. National Institutes of Health.
Ref 527237Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61. Epub 2004 Oct 4.

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