Drug Information

Drug General Information
Drug ID
D02RHV
Former ID
DIB006643
Drug Name
PROXODOLOL
Synonyms
Rac-5-[2-(3-tert-Butylamino-2-hydroxypropoxy)phenoxymethyl]-3-methyl-1,2,4-oxadiazole hydrochloride
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Discontinued in Phase 2 [546580]
Structure
Download
2D MOL

3D MOL
Formula
C17H26ClN3O5
Canonical SMILES
CC(C)(C)NCC(COC1=CC=CC=C1OCC2=NC(=NO2)OC)O.Cl
InChI
1S/C17H25N3O5.ClH/c1-17(2,3)18-9-12(21)10-23-13-7-5-6-8-14(13)24-11-15-19-16(22-4)20-25-15;/h5-8,12,18,21H,9-11H2,1-4H3;1H
InChIKey
IQEOUWNTUSFDSZ-UHFFFAOYSA-N
CAS Number
CAS 158446-41-4
PubChem Compound ID
133046
PubChem Substance ID
29311053, 57344363, 74724892, 104378870, 115354422, 126603667, 131493135, 131549806, 134769757, 135088758, 135570588, 143449636, 162059610, 163117997, 164773305, 165396293, 185982624, 252486718
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [533804]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546580Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009043)
Ref 533804The efficacy of proxodolol, a new beta-adrenoblockader with alpha-adrenoblockader properties, in its single use in patients with stable stenocardia of effort. Eksp Klin Farmakol. 1994 May-Jun;57(3):47-50.

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