Drug Information

Drug General Information
Drug ID
D02SZF
Former ID
DIB008835
Drug Name
18F-SMIBR-K5
Synonyms
SMIBR-K5; RGD-K5-[18F]; Fluorine-18-SMIBR-K5; Cyclic triazole bearing RGD peptide integrin alpha-v beta-3 imaging agent (cancer), Siemens; 18F-RGD-K5
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [532373]
Company
Siemens Medical Solutions Molecular Imaging
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1n(nnc1CCC[18F])CC(=O)NC[C@@H]1O[C@H](C(=O)NCCCC[C@H]2<br />C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](Cc3ccccc3)C(<br />=O)N2)CC(=O)O)CCCNC(=N)N)[C@@H]([C@@H]([C@H]1O)O)O
Target and Pathway
Target(s) Alpha v beta 3 integrin receptor Target Info Modulator [532373]
Reactome Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
MAP2K and MAPK activation
WikiPathways Osteoblast Signaling
Focal Adhesion
Class I MHC mediated antigen processing & presentation
Syndecan interactions
Extracellular matrix organization
Elastic fibre formation
Primary Focal Segmental Glomerulosclerosis FSGS
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wall
Osteopontin Signaling
References
Ref 532373Synthesis of [18F]RGD-K5 by catalyzed [3 + 2] cycloaddition for imaging integrin alphavbeta3 expression in vivo. Nucl Med Biol. 2013 Jul;40(5):710-6.
Ref 532373Synthesis of [18F]RGD-K5 by catalyzed [3 + 2] cycloaddition for imaging integrin alphavbeta3 expression in vivo. Nucl Med Biol. 2013 Jul;40(5):710-6.

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