Drug Information

Drug General Information
Drug ID
D02UHS
Former ID
DIB019119
Drug Name
CGS 24012
Synonyms
DPMA; CGS-24012; CGS24012
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467517]
Structure
Download
2D MOL
Formula
C27H31N5O6
InChI
InChI=1S/C27H31N5O6/c1-15-6-4-5-7-19(15)20(16-8-17(36-2)10-18(9-16)37-3)11-28-25-22-26(30-13-29-25)32(14-31-22)27-24(35)23(34)21(12-33)38-27/h4-10,13-14,20-21,23-24,27,33-35H,11-12H2,1-3H3,(H,28,29,30)/t20?,21-,23-,24-,27-/m1/s1
InChIKey
BUHVIAUBTBOHAG-FOYDDCNASA-N
PubChem Compound ID
10391971
PubChem Substance ID
15407627, 22743132, 34111576, 50382049, 127569247, 135650084, 160686772, 162780187, 225145703, 227070132, 252354294
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Agonist [533734]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467517(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 418).
Ref 533734Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. J Biol Chem. 1995 Jun 9;270(23):13987-97.

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