TTD | Drug: D02VNJ

Drug General Information
Drug ID	D02VNJ
Former ID	DIB009654
Drug Name	CRTH2 antagonists
Synonyms	CRTH2 antagonists (allergic asthma/allergic rhinitis/inflammatory disease); CRTH2 antagonists (allergic asthma/allergic rhinitis/inflammatory disease), Abbott
Indication	Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4]		Investigative	[552092]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(Cc1c2c(n(c1C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)C)scc2)O
Target and Pathway
Target(s)	Putative G-protein coupled receptor 44	Target Info	Antagonist	[543776]
Reactome	Prostanoid ligand receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552092	Thienopyrrole acetic acids as antagonists of the CRTH2 receptor. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1861-4
Ref 543776	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339).

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Drug Information