Drug Information

Drug General Information
Drug ID
D02VZP
Former ID
DIB004943
Drug Name
Flesinoxan
Synonyms
Flesinoxan hydrochloride; DU-29373
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 3 [538607], [544790]
Company
Solvay Pharmaceuticals BV
Structure
Download
2D MOL

3D MOL
Formula
C22H26FN3O4
InChI
InChI=1S/C22H26FN3O4/c23-17-6-4-16(5-7-17)22(28)24-8-9-25-10-12-26(13-11-25)19-2-1-3-20-21(19)29-15-18(14-27)30-20/h1-7,18,27H,8-15H2,(H,24,28)/t18-/m0/s1
InChIKey
NYSDRDDQELAVKP-SFHVURJKSA-N
PubChem Compound ID
57347
PubChem Substance ID
8185186, 17396739, 43115052, 47657096, 47954456, 49876457, 57313895, 79318005, 104312426, 126683320, 134224050, 135016084, 135650267, 136255602, 137249311, 140448268, 160682603, 184545954, 198948621, 223686517, 225051476, 225146319, 226573600
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [525612]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538607(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1).
Ref 544790Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001126)
Ref 525612Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. Eur Neuropsychopharmacol. 1999 Sep;9(5):427-40.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.