Drug Information

Drug General Information
Drug ID
D02WIW
Former ID
DAP001068
Drug Name
Dexbrompheniramine
Synonyms
Dexbromfeniramina; Dexbrompheniraminum; Ilvin; Parabromodylamine; D-Brompheniramine; Dexbromfeniramina [INN-Spanish]; Dexbrompheniramine [INN:BAN]; Dexbrompheniraminum [INN-Latin]; Drixoral (TN); N,N-Dimethyl-(3-(4-bromphenyl)-3-(2-pyridyl)propyl)amin; (+)-brompheniraminum; (3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; (S)-(+)-brompheniramine; (S)-brompheniramine
Drug Type
Small molecular drug
Indication Hay fever; Allergic rhinitis [ICD9: 477, 472.0, 995.3; ICD10:J30, J00, J31.0, T78.4] Approved [538375], [542578], [551871]
Therapeutic Class
Antihistamines
Company
Schering Corp Sub Schering Plough Corp
Structure
Download
2D MOL

3D MOL
Formula
C16H19BrN2
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
InChIKey
ZDIGNSYAACHWNL-HNNXBMFYSA-N
CAS Number
CAS 132-21-8
PubChem Compound ID
16960
PubChem Substance ID
8162708, 29216402, 29284761, 46505186, 47424231, 47499547, 47869645, 47943752, 48243357, 48415865, 50064340, 50110984, 50892258, 57329587, 90341837, 92741717, 104341228, 117389139, 123092153, 124749558, 135051501, 136061981, 137002508, 141867227, 152109073, 160963751, 175267559, 175270118, 179296079, 184545934, 184654397, 210024055, 223365923, 226416446, 249924738, 252346858, 252347937
SuperDrug ATC ID
R06AB06
SuperDrug CAS ID
cas=000132218
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [538137]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538375FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 089116.
Ref 542578(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7588).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 538137H2 histaminergic control of inhibition of eating induced by intragastric NaCl in rats. Physiol Behav. 1998 Aug;65(1):105-13.

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