Drug General Information
Drug ID	D02XLI
Former ID	DIB003325
Drug Name	LY-2979165
Synonyms	Bipolar disorder therapy, Eli Lilly
Indication	Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10:F31, F40-F42]		Discontinued in Phase 1	[523787]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Metabotropic glutamate receptor 2	Target Info	Modulator	[551839]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Cocaine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group II pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523787	ClinicalTrials.gov (NCT01524237) A Study of LY2979165 and LY2140023 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 551839	Annual Reports in Medicinal Chemistry. Volume 47, 2012, Page(78).

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