Drug General Information
Drug ID	D02YBP
Former ID	DIB002209
Drug Name	Mequitamium iodide
Synonyms	LG-30435
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[544538]
Company	Laboratorio Guidotti SpA
Structure		Download 2D MOL 3D MOL
Formula	C21H25IN2S
Canonical SMILES	[C@H]1([C@@H]2CC[N@+](C1)(CC2)C)CN1c2ccccc2Sc2c1cccc2.[<br />I-]
CAS Number	CAS 101396-42-3
PubChem Compound ID	72028
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Modulator	[531768]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544538	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000086)
Ref 531768	High-affinity binding of mequitamium iodide (LG 30435) to muscarinic and histamine H1 receptors. Eur J Pharmacol. 1990 Jul 17;182(3):413-20.

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