Drug Information

Drug General Information
Drug ID
D02YNI
Former ID
DIB004417
Drug Name
OTX-015
Drug Type
Small molecular drug
Indication Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46] Phase 1 [531179], [531260], [543085]
Company
Constellation pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C25H22ClN5O2S
InChI
InChI=1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
InChIKey
GNMUEVRJHCWKTO-FQEVSTJZSA-N
PubChem Compound ID
9936746
Target and Pathway
Target(s) Bromodomain-containing protein 4 Target Info Modulator
Bromodomain-containing protein 2 Target Info Modulator
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Regulation of retinoblastoma protein
WikiPathways Chemical Compounds to monitor ProteinsWP3295:Chemical Compounds to monitor Proteins
References
Ref 531179Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
Ref 531260Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23.
Ref 543085(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8359).

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