Drug Information

Drug General Information
Drug ID
D02ZPE
Former ID
DNC007821
Drug Name
NSC-30552
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529029]
Structure
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2D MOL

3D MOL
Formula
C24H26O6
Canonical SMILES
CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C<br />)C)O)C
InChI
1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChIKey
GNRIZKKCNOBBMO-UHFFFAOYSA-N
PubChem Compound ID
5281650
Target and Pathway
Target(s) Arachidonate 12-lipoxygenase, 12S-type Target Info Inhibitor [529029]
Arachidonate 15-lipoxygenase Target Info Inhibitor [529029]
BioCyc Pathway Lipoxin biosynthesisPWY66-397:Resolvin D biosynthesis
Lipoxin biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa00590:Arachidonic acid metabolism
Linoleic acid metabolism
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL4-mediated signaling events
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid SynthesisWP2650:Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 529029Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Ref 529029Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

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