Drug Information

Drug General Information
Drug ID
D02ZTJ
Former ID
DAP000153
Drug Name
Sulfasalazine
Synonyms
Accucol; Asulfidine; Azopyrin; Azopyrine; Azosulfidin; Azulfadine; Azulfidine; Benzosulfa; Pleon; Reupirin; SASP; SSZ; Salazopiridazin; Salazopyridin; Salazopyrin; Salazosulfapiridina; Salazosulfapyridin; Salazosulfapyridine; Salazosulfapyridinum; Salicylazosulfapyridine; Salisulf; Sulcolon; Sulfasalazin; Sulfasalazina; Sulfasalazinum; Sulfazalazine; Sulphasalazine; Ucine; Ulcol; Alphapharm Brand of Sulfasalazine; Ashbourne Brand of Sulfasalazine; Azulfidine EN; Colo Pleon; FNA Brand of Sulfasalazine; Henning Berlin Brand of Sulfasalazine; Heyl Brand of Sulfasalazine; Medac Brand of Sulfasalazine; Pfizer Brand of Sulfasalazine; Pyralin EN; Ratio Sulfasalazine; Ratiopharm Brandof Sulfasalazine; Sanofi Synthelabo Brand of Sulfasalazine; Sulfasalazin Heyl; Sulfasalazin medac; Sulfasalazine FNA; Sulfasalazine Pfizer Brand; Alti-Sulfasalazine; Azlufidine EN-Tabs; Azulfidine (TN); Azulfidine EN-tabs; Colo-Pleon; EN, Azulfidine; PMS-Sulfasalazine; Ratio-Sulfasalazine; SI-88; Salazo-sulfapyridinum; Salazopyrin (TN); Salazopyrin EN-Tabs; Salazopyrin en-tabs; Salazosulfapiridina [INN-Spanish]; Salazosulfapyridine (JP15); Salazosulfapyridinum [INN-Latin]; Sas-500; Sulfasalazin-Heyl; Sulfasalazina [INN-Spanish]; Sulfasalazine [USAN:INN]; Sulfasalazinum [INN-Latin]; W-t Sasp oral; Sulfasalazine (USP/INN); Pms-Sulfasalazine E.C.; S.A.S. 500; S.A.S. Enteric-500; S.A.S.-500; 13gs; 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID; 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid; 2-hydroxy-5-(4-[(pyridin-2-ylamino)sulfonyl]phenyl}diazenyl)benzoic acid; 2-hydroxy-5-[(E)-{4-[(pyridin-2-ylamino)sulfonyl]phenyl}diazenyl]benzoic acid; 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid; 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene; 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid; 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid; 5-(p-(2-Pyridinylsulfamoyl)Phenylazo)Salicylic Acid; 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid; 5-(para-(2-pyridylsulfamoyl)phenylazo)salicylic acid; 5-[4-(2-Pyridylsulfamoyl)-phenylazo]-salicylic acid; 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid; 5-[p-(2-Pyridylsulfamoyl)phenylazo]salicylic acid; 5-[p-(2-Pyridylsulfamyl)phenylazo]salicylic acid
Drug Type
Small molecular drug
Indication Inflammatory bowel dieasea; Rheumatoid arthritis [ICD9: 555, 556, 714; ICD10:K50, K51, M05-M06] Approved [468074], [536651]
Therapeutic Class
Antiinflammatory Agents
Company
Watson Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C18H14N4O5S
InChI
InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChIKey
NCEXYHBECQHGNR-QZQOTICOSA-N
CAS Number
CAS 599-79-1
PubChem Compound ID
5359476
PubChem Substance ID
9524, 452205, 7847514, 7890377, 10321791, 11112423, 17389737, 26747277, 26747278, 39383787, 46391376, 46505451, 48414442, 48416584, 48424062, 48425604, 49698537, 50105482, 50105483, 53789773, 57361929, 78341122, 85147460, 85164696, 85174423, 85787939, 87560165, 92125445, 93166319, 103914276, 103994509, 104134816, 114147521, 117607242, 124890162, 124890163, 134337474, 134339436, 134976371, 135692179, 139618183, 144204588, 144208437, 144210859, 160964137, 164788662, 170464716, 172386498, 175267319, 179038496
ChEBI ID
ChEBI:9334
SuperDrug ATC ID
A07EC01
SuperDrug CAS ID
cas=000599791
Target and Pathway
Target(s) 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) transformylase Target Info Inhibitor [537956]
References
Ref 468074(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4840).
Ref 536651Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
Ref 537956The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J Immunol. 1996 Mar 1;156(5):1937-41.

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