Drug General Information
Drug ID
D03BAB
Former ID
DNC008860
Drug Name
Cacospongionolide E
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534672]
Structure
Download
2D MOL

3D MOL

Formula
C25H36O4
Canonical SMILES
CC1CCC2(C(C1(C)CCC3=CCC(OC3)C4=CC(=O)OC4O)CCC=C2C)C
InChI
1S/C25H36O4/c1-16-6-5-7-21-24(16,3)12-10-17(2)25(21,4)13-11-18-8-9-20(28-15-18)19-14-22(26)29-23(19)27/h6,8,14,17,20-21,23,27H,5,7,9-13,15H2,1-4H3/t17-,20+,21-,23+,24-,25-/m0/s1
InChIKey
WBDQPITVPUAHAN-DRCQBYJMSA-N
PubChem Compound ID
Target and Pathway
Target(s) Phospholipase A2, membrane associated Target Info Inhibitor [534672]
Phospholipase A2 Target Info Inhibitor [534672]
BioCyc Pathway PhospholipasesLIPASYN-PWY:Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorptionhsa00564:Glycerophospholipid metabolism
Fat digestion and absorption
Pathway Interaction Database Glypican 1 networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PIR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PI
WikiPathways Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Spinal Cord Injury
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophyWP2740:Glycerophospholipid biosynthesis
References
Ref 534672J Nat Prod. 1998 Jul;61(7):931-5.A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
Ref 534672J Nat Prod. 1998 Jul;61(7):931-5.A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.

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