Drug Information
Drug General Information | |||||
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Drug ID |
D03BRM
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Former ID |
DIB018916
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Drug Name |
AUY954
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Synonyms |
AUY 954
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539942] | ||
Structure |
Download2D MOL |
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Formula |
C25H20F3NO2S
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InChI |
InChI=1S/C25H20F3NO2S/c26-25(27,28)21-13-18(7-8-20(21)17-4-2-1-3-5-17)23-14-19-12-16(6-9-22(19)32-23)15-29-11-10-24(30)31/h1-9,12-14,29H,10-11,15H2,(H,30,31)
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InChIKey |
SKYYWSWIUKISCX-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | S1P4 receptor | Target Info | Agonist | [528529] | |
Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [528529] | ||
Sphingosine 1-phosphate receptor 5 | Target Info | Agonist | [528529] | ||
Sphingosine-1-phosphate receptor-2 | Target Info | Agonist | [528529] | ||
Sphingosine-1-phosphate receptor-3 | Target Info | Agonist | [528528] | ||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | ||||
S1P3 pathway | |||||
S1P1 pathway | |||||
Sphingosine 1-phosphate (S1P) pathway | |||||
PDGFR-beta signaling pathways1p_s1p4_pathway:S1P4 pathway | |||||
S1P5 pathway | |||||
Sphingosine 1-phosphate (S1P) pathways1p_s1p3_pathway:S1P3 pathway | |||||
S1P2 pathways1p_s1p3_pathway:S1P3 pathway | |||||
References | |||||
Ref 528528 | Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. Epub2006 Nov 1. | ||||
Ref 528529 | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34. |
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