Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03CFJ
|
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| Former ID |
DIB002709
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| Drug Name |
NCX-701
|
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| Synonyms |
Nitroparacetamol; NO-acetaminophen, NicOx; NO-paracetamol, NicOx
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Discontinued in Phase 2 | [1] | ||
| Company |
NicOx SA
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| Structure |
|
Download2D MOL |
|||
| Formula |
C12H14N2O6
|
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| Canonical SMILES |
[N+](=O)([O-])OCCCC(=O)Oc1ccc(NC(=O)C)cc1
|
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| CAS Number |
CAS 326850-30-0
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Cyclooxygenase | Target Info | Modulator | [2], [3] | |
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014096) | ||||
| REF 2 | Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007 Fall;13(3):279-95. | ||||
| REF 3 | Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. Br J Pharmacol. 2009 September; 158(2): 601-609. | ||||
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