Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03DIG
|
||||
| Former ID |
DAP000213
|
||||
| Drug Name |
Codeine
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Approved | [1], [2] | ||
| Cough [ICD9: 786.2; ICD10:R05] | Phase 1 | [3], [2] | |||
| Therapeutic Class |
Analgesics
|
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| Company |
Forest Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H21NO3
|
||||
| InChIKey |
OROGSEYTTFOCAN-DNJOTXNNSA-N
|
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| CAS Number |
CAS 76-57-3
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
8425, 841961, 7978983, 8144934, 11039235, 14825207, 15419416, 24892429, 24892819, 28325869, 39317728, 46507764, 48413480, 48415816, 48423163, 49855816, 50881119, 53788605, 57653987, 57654027, 87544102, 92710514, 103169342, 103930322, 104000895, 117497011, 124954734, 126631803, 126678046, 128851630, 134337528, 134971680, 135650117, 137001257, 137175320, 142842434, 144207280, 152094958, 160963666, 164838528, 175268396, 175442317, 179151116, 223554832, 223680835, 223739746, 226395484, 241129665
|
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| ChEBI ID |
ChEBI:16714
|
||||
| SuperDrug ATC ID |
R05DA04
|
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| SuperDrug CAS ID |
cas=000076573
|
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| Target and Pathway | |||||
| Target(s) | Delta-type opioid receptor | Target Info | Agonist | [4] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Sphingolipid signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Enkephalin release | |||||
| Opioid proenkephalin pathway | |||||
| Opioid proopiomelanocortin pathway | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074256. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1673). | ||||
| REF 3 | Effects of a mu-opioid receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man. Br J Clin Pharmacol. 1986 Nov;22(5):507-12. | ||||
| REF 4 | Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16. Epub 2005 Jun 8. | ||||
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