Drug Information

Drug General Information
Drug ID
D03DLD
Former ID
DNC014225
Drug Name
H-Tyr-Ala-Phe-Phe-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530745]
Structure
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2D MOL

3D MOL
Formula
C30H35N5O5
Canonical SMILES
CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C(=O)N)NC(<br />=O)C(CC3=CC=C(C=C3)O)N
InChI
1S/C30H35N5O5/c1-19(33-29(39)24(31)16-22-12-14-23(36)15-13-22)28(38)35-26(18-21-10-6-3-7-11-21)30(40)34-25(27(32)37)17-20-8-4-2-5-9-20/h2-15,19,24-26,36H,16-18,31H2,1H3,(H2,32,37)(H,33,39)(H,34,40)(H,35,38)/t19-,24-,25-,26-/m0/s1
InChIKey
MVUYXNQARFGHMJ-UBLBMGLWSA-N
PubChem Compound ID
16760005
Target and Pathway
Target(s) Substance-P receptor Target Info Inhibitor [530745]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

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