Drug General Information
Drug ID	D03DRR
Former ID	DIB011193
Drug Name	Noberastine
Synonyms	Flamizole; R-64947; R-72075
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Phase 2	[544807]
Company	Janssen Pharmaceutica NV
Structure		Download 2D MOL 3D MOL
Formula	C17H21N5O
Canonical SMILES	n1(c(nc2c1nccc2)NC1CCNCC1)Cc1oc(cc1)C
CAS Number	CAS 110588-56-2
PubChem Compound ID	60531
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[528242]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544807	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001178)
Ref 528242	A double-blind placebo controlled dose response study of noberastine on histamine induced weal and flare. Eur J Clin Pharmacol. 1991;40(1):83-5.

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