Drug General Information
Drug ID	D03DTQ
Former ID	DIB015543
Drug Name	PMX-700
Synonyms	SJ-005019; SJ-005059; DC-010-116; Temozolomide analogs (cancer), Pharminox
Indication	Glioblastoma multiforme [ICD9: 191; ICD10:C71]		Investigative	[543657]
Company	Pharminox Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N)c1c2nnn(CC#C)c(=O)n2cn1
Target and Pathway
Target(s)	DNMT1	Target Info	Modulator	[543657]
KEGG Pathway	Cysteine and methionine metabolism
	Metabolic pathways
	MicroRNAs in cancer
Pathway Interaction Database	Regulation of retinoblastoma protein
PathWhiz Pathway	Methionine Metabolism
Reactome	PRC2 methylates histones and DNA
	NoRC negatively regulates rRNA expression
	DNA methylation
WikiPathways	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Trans-sulfuration pathway
References
Ref 543657	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2605).
Ref 543657	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2605).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.