TTD | Drug: D03DTZ

Drug General Information
Drug ID	D03DTZ
Former ID	DIB021257
Drug Name	ZK 756326
Synonyms	ZK-756326; ZK756326
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542981]
Structure		Download 2D MOL
Formula	C21H28N2O3
InChI	InChI=1S/C21H28N2O3/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20/h1-8,17,24H,9-16,18H2
InChIKey	SHDFUNGIHDOLQM-UHFFFAOYSA-N
PubChem Compound ID	11688990
PubChem Substance ID	16793347, 22429997, 23783910, 42855910, 50112915, 79713618, 135651363, 162700760, 170481114, 177748574, 196377596, 242479102, 243131324
Target and Pathway
Target(s)	C-C chemokine receptor type 8	Target Info	Agonist	[527803]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Viral carcinogenesis
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Chemokine receptors bind chemokines
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542981	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 813).
Ref 527803	Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16. Epub 2005 Oct 12.

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Drug Information