Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03EDQ
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| Former ID |
DNAP001262
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| Drug Name |
Vismodegib
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| Synonyms |
Erivedge (TN); Vismodegib (SHH inhibitor)
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| Drug Type |
Small molecular drug
|
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| Indication | Metastatic or locally advanced basal cell carcinoma [ICD9: 173; ICD10:C44] | Approved | [1], [2] | ||
| Company |
Genentech
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H14Cl2N2O3S
|
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| InChI |
InChI=1S/C19H14Cl2N2O3S/c1-27(25,26)13-6-7-14(17(21)11-13)19(24)23-12-5-8-16(20)15(10-12)18-4-2-3-9-22-18/h2-11H,1H3,(H,23,24)
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| InChIKey |
BPQMGSKTAYIVFO-UHFFFAOYSA-N
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| CAS Number |
CAS 879085-55-9
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
49701104, 56182549, 99431642, 99436972, 103596069, 104103799, 124756985, 124950698, 125163790, 126582948, 126723724, 131408297, 131480672, 134221782, 134964405, 135261181, 135264774, 135626713, 135693359, 135727390, 136367283, 136367935, 136920328, 137209785, 137275857, 139063406, 143499146, 144074933, 144116004, 152105953, 152237711, 152258215, 152344224, 160645549, 160647051, 160828460, 162011920, 162037423, 162201437, 163093562, 163390565, 164041956, 164193932, 164766132, 167250332, 170498924, 172919842, 174531169, 175265446, 175427109
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| ChEBI ID |
ChEBI:66903
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| SuperDrug ATC ID |
L01XX43
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | smoothened receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Hedgehog signaling pathway | ||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Basal cell carcinoma | |||||
| PANTHER Pathway | Hedgehog signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | ||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| Reactome | Class B/2 (Secretin family receptors) | ||||
| Hedgehog 'off' state | |||||
| Activation of SMO | |||||
| WikiPathways | Hedgehog Signaling Pathway | ||||
| Hair Follicle Development: Organogenesis (Part 2 of 3) | |||||
| Hair Follicle Development: Induction (Part 1 of 3) | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| GPCR ligand binding | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6975). | ||||
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