| Drug General Information |
| Drug ID |
D03EHB
|
| Former ID |
DNC013784
|
| Drug Name |
3-Bromo-1H-indazole-7-carbonitrile
|
| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H4BrN3
|
| Canonical SMILES |
C1=CC2=C(NN=C2C(=C1)C#N)Br
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| InChI |
1S/C8H4BrN3/c9-8-6-3-1-2-5(4-10)7(6)11-12-8/h1-3H,(H,11,12)
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| InChIKey |
MRGZUAUMTMLMTE-UHFFFAOYSA-N
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| PubChem Compound ID |
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| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
|---|
| Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[1]
|
| Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
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BioCyc Pathway
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Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
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KEGG Pathway
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Arginine and proline metabolism
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Metabolic pathways
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Calcium signaling pathway
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Platelet activation
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Estrogen signaling pathway
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Oxytocin signaling pathwayhsa00220:Arginine biosynthesis
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Peroxisome
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
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Pathways in cancer
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Small cell lung cancerhsa00330:Arginine and proline metabolism
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Phagosome
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Circadian entrainment
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Long-term depression
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Salivary secretion
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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NetPath Pathway
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Wnt Signaling PathwayNetPath_13:IL1 Signaling Pathway
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IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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VEGF signaling pathwayP06959:CCKR signaling map ST
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Pathway Interaction Database
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Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling eventsil12_2pathway:IL12-mediated signaling events
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Alpha9 beta1 integrin signaling events
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ATF-2 transcription factor network
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IL23-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Arginine and Proline Metabolism
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Reactome
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ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeabilityR-HSA-1222556:ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
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WikiPathways
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ACE Inhibitor Pathway
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EGF/EGFR Signaling Pathway
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Myometrial Relaxation and Contraction Pathways
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JAK/STAT
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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Endothelin Pathways
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Leptin signaling pathway
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Effects of Nitric Oxide
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Metabolism of nitric oxide
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AngiogenesisWP619:Type II interferon signaling (IFNG)
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Spinal Cord Injury
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Effects of Nitric OxideWP727:Monoamine Transport
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Amyotrophic lateral sclerosis (ALS)
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Alzheimers Disease
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Serotonin Transporter Activity
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| References |
| REF 1 | Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. Epub 2008 Apr 26.Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. |
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