Drug General Information
Drug ID	D03EHR
Former ID	DIB002869
Drug Name	Lecimibide
Synonyms	DuP-128
Drug Type	Small molecular drug
Indication	Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78]		Terminated	[545142]
Company	Bristol-Myers Squibb Pharma Co
Structure		Download 2D MOL 3D MOL
Formula	C34H40F2N4OS
Canonical SMILES	c1(c([nH]c(n1)SCCCCCN(C(=O)Nc1c(cc(cc1)F)F)CCCCCCC)c1cc<br />ccc1)c1ccccc1
CAS Number	CAS 130804-35-2
PubChem Compound ID	71355
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[533861]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 545142	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002283)
Ref 533861	Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans. Clin Pharmacol Ther. 1994 Jul;56(1):65-74.

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