Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03EHR
|
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| Former ID |
DIB002869
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| Drug Name |
Lecimibide
|
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| Synonyms |
DuP-128
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| Drug Type |
Small molecular drug
|
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| Indication | Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] | Terminated | [1] | ||
| Company |
Bristol-Myers Squibb Pharma Co
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| Structure |
|
Download2D MOL |
|||
| Formula |
C34H40F2N4OS
|
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| Canonical SMILES |
c1(c([nH]c(n1)SCCCCCN(C(=O)Nc1c(cc(cc1)F)F)CCCCCCC)c1cc<br />ccc1)c1ccccc1
|
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| CAS Number |
CAS 130804-35-2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002283) | ||||
| REF 2 | Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans. Clin Pharmacol Ther. 1994 Jul;56(1):65-74. | ||||
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