Drug General Information
Drug ID
D03EOK
Former ID
DNC012490
Drug Name
N-Indan-1-yl-2-(1H-indol-3-yl)-2-oxo-acetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526094]
Structure
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2D MOL

3D MOL

Formula
C19H16N2O2
Canonical SMILES
C1CC2=CC=CC=C2C1NC(=O)C(=O)C3=CNC4=CC=CC=C43
InChI
1S/C19H16N2O2/c22-18(15-11-20-16-8-4-3-7-14(15)16)19(23)21-17-10-9-12-5-1-2-6-13(12)17/h1-8,11,17,20H,9-10H2,(H,21,23)
InChIKey
HPOOEGNMALNZJV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [526094]
Gamma-aminobutyric acid receptor Target Info Inhibitor [526094]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [526094]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [526094]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 526094J Med Chem. 2001 Jul 5;44(14):2286-97.Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.
Ref 526094J Med Chem. 2001 Jul 5;44(14):2286-97.Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.

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