Drug Information

Drug General Information
Drug ID
D03FLT
Former ID
DIB005141
Drug Name
CP-331684
Synonyms
2-[4-[2-[2(R)-(6-Amino-3-pyridinyl)-2-hydroxyethylamino]ethoxy]phenyl]acetic acid
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Phase 2 [547126]
Structure
Download
2D MOL

3D MOL
Formula
C17H21N3O4
Canonical SMILES
C1=CC(=CC=C1CC(=O)O)OCCNCC(C2=CN=C(C=C2)N)O
InChI
1S/C17H21N3O4/c18-16-6-3-13(10-20-16)15(21)11-19-7-8-24-14-4-1-12(2-5-14)9-17(22)23/h1-6,10,15,19,21H,7-9,11H2,(H2,18,20)(H,22,23)/t15-/m0/s1
InChIKey
GZJZZQHTBTUBEL-HNNXBMFYSA-N
CAS Number
CAS 207922-70-1
PubChem Compound ID
9840517
PubChem Substance ID
14801938, 14899829, 24138816, 44938599, 78284095, 128028378, 142483073, 172649702, 198943187, 225061579, 226964578
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [551914]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 547126Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013231)
Ref 551914CN patent application no. 1717230, Pharmaceutical composition comprising a beta-3-adrenoceptor agonist and a serotonin and/or norepinephrine reuptake inhibitor.

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