Drug Information

Drug General Information
Drug ID
D03FQP
Former ID
DIB020318
Drug Name
ME4
Synonyms
EM-A enolether; erythromycin enol ether; ME-4
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538924]
Structure
Download
2D MOL
Formula
C37H65NO12
InChI
InChI=1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChIKey
JFVYXJKGJMUGRG-KJPZRSJGSA-N
PubChem Compound ID
83954
PubChem Substance ID
12015465, 36546040, 49650836, 50064692, 56234602, 57333747, 78742353, 103235129, 104384607, 135040929, 135652704, 136351946, 136351947, 139655622, 198990321, 237215292, 245307049
Target and Pathway
Target(s) Motilin receptor Target Info Agonist [527468]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538924(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1448).
Ref 527468Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. Epub 2005 Mar 11.

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