Drug Information

Drug General Information
Drug ID
D03GFW
Former ID
DNC001175
Drug Name
Pyrilamine Maleate
Drug Type
Small molecular drug
Indication Headache [ICD9: 339, 784.0; ICD10:G43-G44, R51] Approved [536700], [537884]
Structure
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2D MOL

3D MOL
Formula
C21H27N3O5
Canonical SMILES
CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
InChI
1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
JXYWFNAQESKDNC-BTJKTKAUSA-N
CAS Number
CAS 59-33-6
PubChem Compound ID
5284451
PubChem Substance ID
70057, 855902, 8149511, 10321599, 11039284, 17405449, 24277797, 26611903, 26680596, 26747601, 26747602, 39317787, 47207321, 48414401, 48424022, 49854469, 50106737, 50106738, 50106739, 53777996, 56422415, 74505398, 87220220, 91011388, 92124194, 92125164, 92304336, 92307601, 99301263, 103770989, 103914089, 113862915, 121264371, 121361486, 121362835, 124637085, 124800889, 124800890, 134338608, 134340402, 134972293, 135697893, 144075206, 144207712, 144233404, 152090224, 162227138, 163564844, 172829020, 175266358
SuperDrug ATC ID
D04AA02; R06AC01
SuperDrug CAS ID
cas=000091849
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536700], [537884]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.
Ref 537884Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102.
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.
Ref 537884Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102.

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