Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03GGN
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| Former ID |
DIB002438
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| Drug Name |
RO-09-4889
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| Synonyms |
Ro-0094889; 2',3'-Di-O-acetyl-5'-deoxy-5-vinylcytidine
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 1 | [527031] | ||
| Structure |
|
Download2D MOL |
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| Canonical SMILES |
CC1OC(C(OC(=O)C)C1OC(=O)C)N2C=C(C=C)C(=NC2=O)N
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| InChI |
1S/C15H19N3O6/c1-5-10-6-18(15(21)17-13(10)16)14-12(24-9(4)20)11(7(2)22-14)23-8(3)19/h5-7,11-12,14H,1H2,2-4H3,(H2,16,17,21)
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| InChIKey |
NELWQUQCCZMRPB-UHFFFAOYSA-N
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| CAS Number |
CAS 216449-60-4
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| Target and Pathway | |||||
| Target(s) | Dihydropyrimidine dehydrogenase [NADP+] | Target Info | Modulator | [527031], [531635] | |
| PANTHER Pathway | Pyrimidine Metabolism | ||||
| PathWhiz Pathway | Beta-Alanine Metabolism | ||||
| Pyrimidine Metabolism | |||||
| WikiPathways | Metabolism of nucleotides | ||||
| Fluoropyrimidine Activity | |||||
| References | |||||
| Ref 527031 | Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889. Clin Cancer Res. 2004 Apr 1;10(7):2327-35. | ||||
| Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
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