Drug Information
Drug General Information | |||||
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Drug ID |
D03HNC
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Former ID |
DNC011656
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Drug Name |
N-hydroxy-4-(naphthalen-1-yl)benzamide
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Synonyms |
N-Hydroxy-4-naphthalen-1-yl-benzamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
Download2D MOL |
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Formula |
C17H13NO2
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Canonical SMILES |
C1=CC=C2C(=C1)C=CC=C2C3=CC=C(C=C3)C(=O)NO
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InChI |
1S/C17H13NO2/c19-17(18-20)14-10-8-13(9-11-14)16-7-3-5-12-4-1-2-6-15(12)16/h1-11,20H,(H,18,19)
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InChIKey |
PKQVYJOPUCLLCD-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Histone Deacetylase 8 | Target Info | Inhibitor | [1] | |
Arachidonate 5-lipoxygenase | Target Info | Inhibitor | [2] | ||
BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
Resolvin D biosynthesis | |||||
Leukotriene biosynthesis | |||||
Lipoxin biosynthesis | |||||
Aspirin triggered resolvin D biosynthesis | |||||
Aspirin triggered resolvin E biosynthesis | |||||
KEGG Pathway | Alcoholism | ||||
Viral carcinogenesishsa00590:Arachidonic acid metabolism | |||||
Metabolic pathways | |||||
Serotonergic synapse | |||||
Ovarian steroidogenesis | |||||
Toxoplasmosis | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
PANTHER Pathway | Wnt signaling pathway | ||||
Pathway Interaction Database | Signaling events mediated by HDAC Class I | ||||
PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
Reactome | NOTCH1 Intracellular Domain Regulates Transcription | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
HDACs deacetylate histones | |||||
WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
Neural Crest Differentiation | |||||
Cell CycleWP2877:Vitamin D Receptor Pathway | |||||
Arachidonic acid metabolism | |||||
Eicosanoid Synthesis | |||||
Selenium Micronutrient Network | |||||
References | |||||
REF 1 | Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. | ||||
REF 2 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
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