Drug Information

Drug General Information
Drug ID
D03IES
Former ID
DIB019681
Drug Name
cyPPTS
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541414]
Structure
Download
2D MOL
Formula
C19H21F3N2O3S
InChI
InChI=1S/C19H21F3N2O3S/c20-19(21,22)14-28(25,26)24(13-15-5-4-10-23-12-15)16-6-3-9-18(11-16)27-17-7-1-2-8-17/h3-6,9-12,17H,1-2,7-8,13-14H2
InChIKey
WCYYNLFGFUQJMF-UHFFFAOYSA-N
PubChem Compound ID
44335556
PubChem Substance ID
90016694, 103323488, 104035695, 178102877, 232426414
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [527442]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541414(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6257).
Ref 527442Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology (Berl). 2005Apr;179(1):271-83. Epub 2005 Feb 17.

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