Drug Information

Drug General Information
Drug ID
D03JQR
Former ID
DND000048
Drug Name
RG-7273
Synonyms
RG 7273; RG7273
Indication Lipid metabolism disorder [ICD10:E75-E78] Discontinued in Phase 1 [549025]
Company
Hoffmann-La Roche
Target and Pathway
Target(s) ATP-binding cassette, sub-family A, member 1 Target Info Inducer [543959]
KEGG Pathway ABC transporters
Fat digestion and absorption
NetPath Pathway Leptin Signaling Pathway
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome HDL-mediated lipid transport
PPARA activates gene expression
WikiPathways Statin Pathway
Nuclear Receptors in Lipid Metabolism and Toxicity
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Lipid digestion, mobilization, and transport
SREBF and miR33 in cholesterol and lipid homeostasis
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 549025Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031594)
Ref 543959(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 756).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.