Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03JRJ
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| Former ID |
DIB011983
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| Drug Name |
NTE-122
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| Synonyms |
ACAT inhibitor, Nissin Food
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| Indication | Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] | Terminated | [1] | ||
| Company |
Nissin Foods Holdings Co Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
C(=O)(N(C[C@H]1CC[C@H](CN(C(=O)Nc2ccc(N(C)C)cc2)C2CCCCC<br />2)CC1)C1CCCCC1)Nc1ccc(N(C)C)cc1
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| CAS Number |
CAS 166967-85-7
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| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008195) | ||||
| REF 2 | Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol. 1998 Nov;78(3):355-64. | ||||
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