Drug Information

Drug General Information
Drug ID
D03KTK
Former ID
DIB013256
Drug Name
TAK-937
Synonyms
Cerebroprotectant (acute stroke, injection), Takeda; CB1/CB2 receptor agonist (acute stroke, injection), Takeda
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Discontinued in Phase 1 [548963]
Company
Takeda Pharmaceutical Co Ltd
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Modulator [531715]
Cannabinoid receptor 1 Target Info Modulator [531715]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 548963Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030875)
Ref 531715Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. Brain Res. 2012 Jan 9;1430:93-100.

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