Drug Information

Drug General Information
Drug ID
D03KTU
Former ID
DNC009446
Drug Name
BMS-561388
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Investigative [530071]
Structure
Download
2D MOL

3D MOL
Formula
C27H35N5O6S
Canonical SMILES
CC1=C(C=CC(=C1)OC)C2=C3N=C(N=C(N3N=C2C)N(CCOC)CCOC)C.C1<br />=CC=C(C=C1)S(=O)(=O)O
InChI
1S/C21H29N5O3.C6H6O3S/c1-14-13-17(29-6)7-8-18(14)19-15(2)24-26-20(19)22-16(3)23-21(26)25(9-11-27-4)10-12-28-5;7-10(8,9)6-4-2-1-3-5-6/h7-8,13H,9-12H2,1-6H3;1-5H,(H,7,8,9)
InChIKey
ZQUBMILBXQLTDU-UHFFFAOYSA-N
PubChem Compound ID
11249907
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Inhibitor [530071]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 530071J Med Chem. 2009 May 14;52(9):3073-83.8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
Ref 530071J Med Chem. 2009 May 14;52(9):3073-83.8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.

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