Drug Information
Drug General Information | |||||
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Drug ID |
D03LAB
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Former ID |
DIB010931
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Drug Name |
TBC-3711
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Synonyms |
N-(2-Acetyl-4,6-dimethylphenyl)-3-[N-(3,4-dimethylisoxazol-5-yl)sulfamoyl]thiophene-2-carboxamide
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Drug Type |
Small molecular drug
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Indication | Hypotension [ICD9: 458, 796.3; ICD10:I95] | Phase 2 | [1] | ||
Company |
Encysive Pharmaceuticals
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Structure |
Download2D MOL |
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Formula |
C20H21N3O5S2
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Canonical SMILES |
CC1=CC(=C(C(=C1)C(=O)C)NC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(<br />C(=NO3)C)C)C
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InChI |
1S/C20H21N3O5S2/c1-10-8-11(2)17(15(9-10)14(5)24)21-19(25)18-16(6-7-29-18)30(26,27)23-20-12(3)13(4)22-28-20/h6-9,23H,1-5H3,(H,21,25)
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InChIKey |
IAYNHDZSSDUYHY-UHFFFAOYSA-N
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CAS Number |
CAS 374680-51-0
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Endothelin-1 receptor | Target Info | Antagonist | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
cGMP-PKG signaling pathway | |||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
Vascular smooth muscle contraction | |||||
Renin secretion | |||||
Pathways in cancer | |||||
NetPath Pathway | IL4 Signaling Pathway | ||||
PANTHER Pathway | Endothelin signaling pathway | ||||
Pathway Interaction Database | Endothelins | ||||
EGFR-dependent Endothelin signaling events | |||||
Reactome | Peptide ligand-binding receptors | ||||
G alpha (q) signalling events | |||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Peptide GPCRs | |||||
Endothelin Pathways | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT00272961) A Study Of Different Doses Of TBC3711 In Patients With Uncontrolled High Blood Pressure Already Taking Medications For High Blood Pressure.. U.S. National Institutes of Health. | ||||
REF 2 | TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets. Pediatr Res. 2001 Sep;50(3):374-83. | ||||
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