TTD | Drug: D03LDH

Drug General Information
Drug ID	D03LDH
Former ID	DNC004833
Drug Name	1-Benzyl-4-chroman-2-ylmethyl-piperazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527368]
Structure		Download 2D MOL 3D MOL
Formula	C21H26N2O
Canonical SMILES	C1CC2=CC=CC=C2OC1CN3CCN(CC3)CC4=CC=CC=C4
InChI	1S/C21H26N2O/c1-2-6-18(7-3-1)16-22-12-14-23(15-13-22)17-20-11-10-19-8-4-5-9-21(19)24-20/h1-9,20H,10-17H2
InChIKey	AJZBPCAHQHCXMX-UHFFFAOYSA-N
PubChem Compound ID	10758200
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[527368]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 527368	J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.
Ref 527368	J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands.

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Drug Information