Drug Information

Drug General Information
Drug ID
D03MAD
Former ID
DCL000507
Drug Name
CP-800569
Synonyms
(2R)-3-[3-(4-chloro-3-ethylphenoxy)-N-[[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]anilino]-1,1,1-trifluoropropan-2-ol
Drug Type
Small molecular drug
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Discontinued in Phase 1 [548431]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C26H23ClF7NO3
Canonical SMILES
CCC1=C(C=CC(=C1)OC2=CC=CC(=C2)N(CC3=CC(=CC=C3)OC(C(F)F)<br />(F)F)CC(C(F)(F)F)O)Cl
InChI
1S/C26H23ClF7NO3/c1-2-17-12-20(9-10-22(17)27)37-19-7-4-6-18(13-19)35(15-23(36)25(30,31)32)14-16-5-3-8-21(11-16)38-26(33,34)24(28)29/h3-13,23-24,36H,2,14-15H2,1H3/t23-/m1/s1
InChIKey
VHSPKQAESIGBIC-HSZRJFAPSA-N
PubChem Compound ID
6918520
PubChem Substance ID
12015419, 14813011, 15208046, 17194938, 43529890, 74970928, 103263320, 104019910, 114788100, 134339095, 142205299, 226644584, 244706454
Target and Pathway
Target(s) Cholesteryl ester transfer protein Target Info Inhibitor [549974], [551502]
PANTHER Pathway CCKR signaling map ST
Reactome LDL-mediated lipid transport
HDL-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 548431Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025536)
Ref 549974Pfizer. Product Development Pipeline. March 31 2009.
Ref 551502Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. A structure-activity relationship study. Oncol Res. 2003;13(11):463-9.

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