Drug Information

Drug General Information
Drug ID
D03MUM
Former ID
DIB009194
Drug Name
EDONENTAN HYDRATE
Synonyms
Edonentan hydrate < USAN; Prop INNM >; BMS-207940 (anhydrous); BMS-207940-02; N-[2'-(4,5-Dimethylisoxazol-3-ylsulfamoyl)-4-(2-oxazolyl)biphenyl-2-ylmethyl]-N,3,3-trimethylbutyramide hydrate
Indication Pulmonary arterial hypertension [ICD9: 416; ICD10:I27.0, I27.2] Discontinued in Phase 2 [547387]
Structure
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2D MOL

3D MOL
Canonical SMILES
CN(Cc1cc(ccc1c2ccccc2S(=O)(=O)Nc3noc(C)c3C)c4occn4)C(=O<br />)CC(C)(C)C
InChI
1S/C28H32N4O5S/c1-18-19(2)37-30-26(18)31-38(34,35)24-10-8-7-9-23(24)22-12-11-20(27-29-13-14-36-27)15-21(22)17-32(6)25(33)16-28(3,4)5/h7-15H,16-17H2,1-6H3,(H,30,31)
InChIKey
ORJRYNKVKJAJPY-UHFFFAOYSA-N
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [550931], [551871]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547387Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015788)
Ref 550931US patent application no. 9,062,094, Dipeptide-based prodrug linkers for aliphatic amine-containing drugs.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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