Drug Information

Drug General Information
Drug ID
D03MUZ
Former ID
DNC008527
Drug Name
8-chloro-quinoline-3-carbonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529035]
Structure
Download
2D MOL

3D MOL
Formula
C20H13Cl2FN6
Canonical SMILES
C1=CC(=C(C=C1NC2=C(C=NC3=C(C=C(C=C32)NCC4=CN=CN4)Cl)C#N<br />)Cl)F
InChI
1S/C20H13Cl2FN6/c21-16-4-12(1-2-18(16)23)29-19-11(6-24)7-27-20-15(19)3-13(5-17(20)22)26-9-14-8-25-10-28-14/h1-5,7-8,10,26H,9H2,(H,25,28)(H,27,29)
InChIKey
ONXROKMQGCSOMG-UHFFFAOYSA-N
PubChem Compound ID
17759555
Target and Pathway
Target(s) Stromelysin-1 Target Info Inhibitor [529035]
mRNA of human cot oncogene Target Info Inhibitor [529035]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04010:MAPK signaling pathway
Toll-like receptor signaling pathway
T cell receptor signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00054:Toll receptor signaling pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingtcr_pathway:TCR signaling in na&#xef
TCR signaling in na&#xef
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Ras signaling in the CD4+ TCR pathway
JNK signaling in the CD4+ TCR pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-389357:CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP75:Toll-like receptor signaling pathway
TCR Signaling Pathway
Insulin Signaling
MAPK Signaling Pathway
Structural Pathway of Interleukin 1 (IL-1)
TNF alpha Signaling Pathway
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Interleukin-1 signaling
Costimulation by the CD28 family
Regulation of toll-like receptor signaling pathway
References
Ref 529035J Biol Chem. 2007 Nov 16;282(46):33295-304. Epub 2007 Sep 11.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Ref 529035J Biol Chem. 2007 Nov 16;282(46):33295-304. Epub 2007 Sep 11.Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.